Miami, FL, October 25, 2025

News Summary

As the 2025 MLS Cup approaches, Inter Miami CF has emerged as the frontrunner with +400 odds for victory, driven by Lionel Messi’s stellar performance. Following them are the Philadelphia Union at +500 and Vancouver Whitecaps FC at +600. Newly introduced San Diego FC has shown promise with +700 odds, while Los Angeles FC and FC Cincinnati follow closely. The playoffs promise to be thrilling, kicking off with Inter Miami facing Nashville SC, which they recently defeated 5-2 with Messi scoring a hat trick.

Miami, FL

The 2025 MLS Cup, set for December 6, is heating up as Inter Miami CF emerges as the favorite to take home the coveted trophy. According to recent betting odds published by DraftKings, Inter Miami leads the pack with odds of +400, thanks to star player Lionel Messi’s impressive performances throughout the season.

Following closely behind are the Philadelphia Union, with odds of +500, and the Vancouver Whitecaps FC, who are positioned third with odds of +600. San Diego FC, newly introduced in the league, has also made a notable impact in its expansion season, sitting at +700 in the betting lines. Los Angeles FC follows with odds of +750, while FC Cincinnati stands at +1000.

The odds continue with the Seattle Sounders FC at +1600. New York City FC and the Columbus Crew are even at +2000. Meanwhile, Charlotte FC, Nashville SC, and Minnesota United FC are tied at +2500. The Chicago Fire FC, Austin FC, and Portland Timbers all have odds of +5000, and FC Dallas is seen as the least favored team at +8000.

The first round of the MLS playoffs, which consists of best-of-three series, will kick off soon. Inter Miami is set to face Nashville SC, a team they defeated 5-2 in their most recent encounter, where Messi notably scored a hat trick. Inter Miami secured the third spot in the Eastern Conference standings with a total of 65 points this season. Noteworthy wildcard entries such as the Chicago Fire and Portland Timbers made their way into the playoffs, each securing a wildcard win. The Fire won their latest game 3-1 against Orlando City, while the Timbers also triumphed with a 3-1 victory over Real Salt Lake.

The playoff schedule spans multiple matches from October 24 to November 9 for the first round. Subsequent rounds will transition to a single-elimination format, leading to the conference semifinals slated for November 22-23, and culminating in the conference finals on November 29-30.

2025 MLS Cup Betting Odds

• Inter Miami CF: +400
• Philadelphia Union: +500
• Vancouver Whitecaps FC: +600
• San Diego FC: +700
• LAFC: +750
• FC Cincinnati: +1000
• Seattle Sounders FC: +1600
• New York City FC: +2000
• Columbus Crew: +2000
• Charlotte FC: +2500
• Nashville SC: +2500
• Minnesota United FC: +2500
• Chicago Fire FC: +5000
• Austin FC: +5000
• Portland Timbers: +5000
• FC Dallas: +8000

Playoff Format Overview

The first round of the playoffs is a best-of-three series, which will include games from October 24 to November 9. The progression will shift to a single-elimination format for subsequent rounds, with important dates including the conference semifinals on November 22-23 and the conference finals on November 29-30.

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Additional Resources

• MLS Soccer: MLS Cup 2025 Odds
• Athlon Sports: Inter Miami vs Nashville SC
• USA Today: MLS Playoff Predictions
• New York Times: MLS Cup 2025 Playoff Bracket
• Sports Illustrated: Complete MLS Cup Playoff Bracket

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